Gene name:
CLEC7A (UNQ539/PRO1082;BGR;CLECSF12;DECTIN1) ;
Protein name:
C-type lectin domain family 7 member A ;
Alternative:
C-type lectin superfamily member 12 ;Beta-glucan receptor ;Dendritic cell-associated C-type lectin 1 (DC-associated C-type lectin 1;Dectin-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer (By similarity). Isoform 5 interacts with RANBP9.
Function:
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
Subcellular Location:
Isoform 7
Cytoplasm
Protein Attributes:
50:
MEYHPDLENL | DEDGYTQLHF | DSQSNTRIAV | VSEKGSCAAS | PPWRLIAVIL |
100:
GILCLVILVI | AVVLGTMAIW | RSNSGSNTLE | NGYFLSRNKE | NHSQPTQSSL |
150:
EDSVTPTKAV | KTTGVLSSPC | PPNWIIYEKS | CYLFSMSLNS | WDGSKRQCWQ |
200:
LGSNLLKIDS | SNELGFIVKQ | VSSQPDNSFW | IGLSRPQTEV | PWLWEDGSTF |
247:
SSNLFQIRTT | ATQENPSPNC | VWIHVSVIYD | QLCSVPSYSI | CEKKFSM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Human C-type lectin domain family 7 member A
ELISA Kit for Human C-type lectin domain family 7 member A
ELISA Kit for Human C-type lectin domain family 7 member A
CLIA Kit for Human C-type lectin domain family 7 member A
CLIA Kit for Human C-type lectin domain family 7 member A
CLIA Kit for Human C-type lectin domain family 7 member A
Polyclonal Antibody for Human C-type lectin domain family 7 member A
Polyclonal Antibody for Human C-type lectin domain family 7 member A
Polyclonal Antibody for Human C-type lectin domain family 7 member A
Monoclonal Antibody for Human C-type lectin domain family 7 member A
Monoclonal Antibody for Human C-type lectin domain family 7 member A
Monoclonal Antibody for Human C-type lectin domain family 7 member A
Protein for Human C-type lectin domain family 7 member A
Protein for Human C-type lectin domain family 7 member A
Protein for Human C-type lectin domain family 7 member A
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Peripheral blood leukocyte .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Peripheral blood leukocyte .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INDUCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 7)
tissue :
Umbilical cord blood .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 9)
tissue :
Colon .
tissue :
Lung .
tissue :
Urinary bladder .
11.
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Cited for : INTERACTION WITH RANBP9;SUBCELLULAR LOCATION
12.
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Cited for : FUNCTION;SUBCELLULAR LOCATION
13.
"Human dectin-1 deficiency and mucocutaneous fungal infections."
Ferwerda B.
,
Ferwerda G.
,
Plantinga T.S.
,
Willment J.A.
,
van Spriel A.B.
,
Venselaar H.
,
Elbers C.C.
,
Johnson M.D.
,
Cambi A.
,
Huysamen C.
,
Jacobs L.
,
Jansen T.
,
Verheijen K.
,
Masthoff L.
,
Morre S.A.
,
Vriend G.
,
Williams D.L.
,
Perfect J.R.
,
Joosten L.A.
,
Wijmenga C.
,
van der Meer J.W.
,
Adema G.J.
,
Kullberg B.J.
,
Brown G.D.
,
Netea M.G.
more...
N. Engl. J. Med.361:1760-1767(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INVOLVEMENT IN CANDF4
14.
"Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity."
Cunha C.
,
Di Ianni M.
,
Bozza S.
,
Giovannini G.
,
Zagarella S.
,
Zelante T.
,
D'Angelo C.
,
Pierini A.
,
Pitzurra L.
,
Falzetti F.
,
Carotti A.
,
Perruccio K.
,
Latge J.P.
,
Rodrigues F.
,
Velardi A.
,
Aversa F.
,
Romani L.
,
Carvalho A.
Blood116:5394-5402(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : POLYMORPHISM